ICBO_2018_7: A Quality Assurance Methodology for ChEBI Ontology Focusing on Uncommonly Modeled Concepts

TitleICBO_2018_7: A Quality Assurance Methodology for ChEBI Ontology Focusing on Uncommonly Modeled Concepts
Publication TypeConference Paper
Year of Publication2018
AuthorsLiu, H, Chen, L, Zheng, L, Perl, Y, Geller, J
Conference NameInternational Conference on Biomedical Ontology (ICBO 2018)
Date Published08/06/2018
PublisherInternational Conference on Biological Ontology
KeywordsChEBI, chemical concept, chemical ontology, modeling error, quality assurance
Abstract

The Chemical Entities of Biological Interest (ChEBI) ontology is an important knowledge source of chemical entities in a biological context. ChEBI is large and complex, making it almost impossible to be error-free, given the scarce resources for quality assurance (QA). We present a methodology to locate concepts in ChEBI with a high probability of being erroneous. An Abstraction Network, which provides a compact summarization of an ontology, supports the methodology. By investigating a sample of ChEBI concepts, we show that uncommonly modeled concepts residing in small units of the Abstraction Network of ChEBI are statistically significantly more likely to have errors than other concepts. The finding may guide ChEBI ontology curators to focus their limited QA resources on such concepts to achieve a better QA yield. Furthermore, this study, combined with previous work, contributes to progress in showing that this methodology can be applied to a whole family of similar ontologies.

URLhttp://icbo2018.cgrb.oregonstate.edu/